Protein Details: Aquaporin-3

Protein ID

ICDB_Pro_1371

Protein Name

Aquaporin-3

Gene Name

AQP3

Organism

Homo sapiens (Human)

Length

292 amino acids

AlphaFoldDB

AF-Q92482-F1-model_v4.pdb

Function

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration;wound healing;and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water;thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).

Sequence

MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Keratomalacia and Acrocephalopolysyndactyly Type Iii

Location

Widely expressed in epithelial cells of kidney (collecting ducts) and airways;in keratinocytes;immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.

DOI ID

10.1006/geno.1995.1055; 10.1074/jbc.m208999200; 10.1038/ng1285; 10.1038/nature02465; 10.1101/gr.2596504; 10.1016/j.ejphar.2008.03.063; 10.1038/s41467-018-07176-z

RefSeq

NP_001305073.1; NP_004916.1 [Q92482-1]